The Bonacini cirrhosis discriminant score is calculated by giving points for the following parameters [50]:

●Platelets (x1000/mm3):

•>340 – zero points

•280 to 339 – one point

•220 to 279 – two points

•160 to 219 – three points

•100 to 159 – four points

•40 to 99 – five points

•<40 – six points

●Alanine aminotransferase to aspartate aminotransferase (ALT/AST) ratio:

•>1.7 – zero points

•1.2 to 1.7 – one point

•0.6 to 1.19 – two points

•<0.6 – three points

●International normalized ratio (INR):

•<1.1 – zero points

•1.1 to 1.4 – one point

•>1.4 – two points

Factors associated with a low likelihood of cirrhosis included:

●Lok index <20 percent (LR 0.09)

●Platelet count of 160,000/mm3 or higher (LR 0.29)

●Absence of hepatomegaly (LR 0.37)

The Lok index is calculated using the platelet count, AST, ALT, and INR [51]. In a validation study, when a cutoff of <20 percent was used to exclude cirrhosis, the test had a specificity of 92 percent. When a cutoff of >50 percent was used to diagnose cirrhosis, the test had a sensitivity of 85 percent.