The new equation, named the EKFC equation after the European Kidney Function Consortium that developed it, depends on adjustments to an individual's serum creatinine and cystatin C values that derive from median values in healthy populations across the age spectrum (including children and adults), sex, and race. (Sex and race adjustments are not needed for cystatin C but are required when creatinine is the input variable.)
Researchers introduced the EKFC equation with the adjustment factor for serum creatinine in 2021, and in their report describing the equation's derivation and validation they concluded that the EKFC equation "shows improved accuracy and precision compared with commonly used equations for estimating GFR from serum creatinine levels."